Table 1:

Demographic characteristics and underlying disease

	Study cohort (n = 247)	Incidence TMA (n = 11)	Univariable analysis
			P-value	Odds ratio
Age (years)	64 (56–73)	68 (61–72)	0.205	1.038 (0.980–1.099)
Female gender	70	4 (6)	0.015	4.806 (1.361–16.973)
BMI (kg/m2)	26 (24–29)	26 (21–30)	0.524	0.956 (0.831–1.099)
Aortic pathology
Aneurysm	165	7 (4)	0.820	0.864 (0.246–3.040)
Chronica/residualb dissection	19	2 (11)	0.200	2.863 (0.572–14.317)
Acute aortic syndromec	53	1 (2)	0.327	0.354 (0.044–2.828)
Endocarditis/prosthetic infection	10	1 (1)	0.401	2.522 (0.291–21.890)
Aortic valve pathology
Stenosis	50	2 (4)	0.862	0.870 (0.182–4.161)
Insufficiency	205	9 (4)	0.915	0.918 (0.191–4.412)
Bicuspid morphology	83	2 (2)	0.400	0.504 (0.102–2.486)
Valve prosthesis in situ	14	2 (14)	0.089	4.148 (0.806–21.353)
Biological type	7	1 (14)	0.919	1.167 (0.059–22.937)

Data are shown as median (0.25–0.75 percentile), n (%) or odds ratio (95% confidence interval), bold: statistically significant.

^aOccurrence ≥14 days ago.

^bPersistent/progredient disease after surgically corrected dissection.

^cIncludes aortic dissection, intramural haematoma and symptomatic penetrating aortic ulcer.

BMI: body mass index; TMA: thrombotic microangiopathy.