Table 3:
Surgical data
| Study cohort (n = 247) | Incidence TMA (n = 11) | Univariable analysis |
||
|---|---|---|---|---|
| P-value | Odds ratio | |||
| Extracorporeal circulation | ||||
| CPB time (min) | 203 (164–246) | 217 (164–267) | 0.418 | 1.004 (0.995–1.012) |
| Cross-clamp time (min) | 138 (111–165) | 147 (112–194) | 0.229 | 1.007 (0.995–1.020) |
| HCA time (min) | 25 (20–46) | 28 (21–36) | 0.820 | 0.996 (0.965–1.028) |
| SACP time (min) | 22 (16–41) | 26 (18–34) | 0.816 | 0.997 (0.970–1.024) |
| Lowest core temperature (°C) | 25 (23.7–25.5) | 24.4 (23.4–25.5) | 0.477 | 1.123 (0.816–1.545) |
| SACP temperature (°C) | 22.0 | 22.0 | 0.143 | 1.770 (0.824–3.802) |
| Cardioplegia (ml) | 2140 (1900–2440) | 2140 (1910–2440) | 0.935 | 1.000 (0.998–1.002) |
| Proximal site | ||||
| Aortic valve repair | 56 | 1 (2) | 0.294 | 0.329 (0.041–2.628) |
| David | 29 | 0 (–) | 0.998 | <0.001 (–) |
| Root-sparing (Frater) | 27 | 1 (4) | 0.842 | 0.808 (0.099–6.567) |
| Aortic valve replacement | 145 | 10 (7) | 0.057 | 7.481 (0.942–59.392) |
| Bentall | 98 | 7 (7) | 0.110 | 2.788 (0.794–9.792) |
| Root-sparing | 47 | 3 (6) | 0.480 | 1.636 (0.417–6.419) |
| Distal site | ||||
| Proximal arch replacement | 205 | 10 (5) | 0.484 | 2.103 (0.262–16.881) |
| Total arch replacement | 42 | 1 (2) | 0.484 | 0.476 (0.059–3.819) |
| w/FET | 34 | 1 (3) | 0.648 | 0.615 (0.076–4.965) |
| Concomitant procedures | 121 | 6 (5) | 0.707 | 1.263 (0.375–4.251) |
| Reoperation | 30 | 3 (10) | 0.132 | 2.903 (0.726–11.609) |
Data are shown as median (0.25–0.75 percentile), n (%) or odds ratio (95% confidence interval), bold: statistically significant.
CPB: cardiopulmonary bypass; FET: frozen elephant trunk; HCA: hypothermic circulatory arrest; SACP: selective antegrade cerebral perfusion; TMA: thrombotic microangiopathy.