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. 2022 Mar 8;11(2):200–212. doi: 10.1093/stcltm/szab014

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 6. — Endogenous repair of injured dura mater in the Prx1^{CreERT2−GFP+/+}R26R^tdTomato+/+ (A-C) and Hic1^CreERT2+/+R26R^tdTomato+/+ mice (D-F). Histological (A, D) and corresponding Ki67 (B, E) and α-SMA (C, F) images are presented. The dura mater is outlined by the dashed line while the epidural fat is encircled by the solid line. Asterisks indicate granulation tissue adjacent to the dural injury (A, D). Arrows indicate examples of Prx1⁺ and Hic1⁺ MPCs within the dural injury site. Quantification of Prx1⁺ and Hic1⁺ MPCs within the dural injury site (G). An n = 3 mice were used per group. ∗∗P < .01, ∗∗∗P < .001. Scale bars = 100 µm. Abbreviations: Hic1, hypermethylated in cancer 1; MPCs, mesenchymal progenitor cells; Prx1, paired related homeobox-1; α-SMA, alpha-smooth muscle actin.