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. 2022 Mar 17;17(3):e0264321. doi: 10.1371/journal.pone.0264321

Table 4. Fasted serum concentrations of glucose, cholesterol, NEFA, TAG, LDL, VLDL, HDL-C, ALT, and ALP of post-gonadectomy kittens supplemented with additional choline at 300 mg/kg BW0.75 (CHOLINE, n = 8) compared to a group fed only the base diet (CONTROL, n = 7) over 12 weeks.

Week CHOLINE (n = 8) CONTROL (n = 7) P-Values
LSM SEM LSM SEM PGroup PTime PGroup*Time
Glucose (mmol/L) -1 15.68 0.69 15.85 0.73 0.491 0.140 0.639
12 14.22 15.08
Cholesterol (mmol/L) -1 4.36 0.18 4.42 0.19 0.607 0.716 0.395
12 4.45 4.20
NEFA (mmol/L) -1 0.31 0.03 0.29 0.03 0.174 0.715 0.091
12 0.26 0.37
TAG (mmol/L) -1 0.39 0.04 0.40 0.04 0.156 0.134 0.480
12 0.43 0.50
LDL (mmol/L) -1 1.03 0.08 1.10 0.08 0.181 <0.0001 0.151
12 0.60 0.37
VLDL (mmol/L) -1 0.18 0.02 0.18 0.02 0.153 0.133 0.476
12 0.19 0.23
HDL-C (mmol/L) -1 3.13 0.17 3.13 0.18 0.209 0.002 0.212
12 4.06 3.59
ALT (U/L) -1 37.0 4.09 35.0 4.37 0.373 0.011 0.167
12 43.63 53.43
ALP (U/L) -1 95.0 8.55 100.14 9.14 0.580 <0.0001 0.726
12 53.50 61.71

ALT, Alanine Aminotransferase; ALP, alkaline phosphatase; HDL-C, high-density lipoprotein cholesterol; LDL, low-density lipoprotein; LSM, least square means; NEFA, non-esterified fatty acid; SEM, standard error of the mean; TAG, triacylglyceride; VLDL, very low-density lipoprotein