Table 1. Description of included studies: ED setting.

Study	Inclusion criteria	Exclusion criteria	Mean/Median age (years)	% Male	Sample size	Outcome	EWS	Cut-off points	SEN%	SPE%	AUC/OR (95% CI)	ROB
Jiang et al. 2019 [22]	Multiple trauma	Age < 16yrs and missing data, DOA, medical patients	48.0	73.7	1127	28 days in-hospital mortality	MEWS	≥3	93.0	75.0	0.78	Poor
Demircan et al. 2020 [23]	Age ≥65yrs, Yellow or red triage code	TRI, CPR prior arrival, loss of contacts	77.2	52.0	1106	28 days in-hospital mortality	MEWS	≥3	58.4	65.3	0.65	Good
Mitsunaga et al. 2019 [24]	Age ≥65yrs	N/S	78.0	53.9	2204	28 days in-hospital mortality	NEWS	≥5	78.7	64.0	0.79	Good
						28 days in-hospital mortality	MEWS	≥3	69.3	67.6	0.72
Koksal et al. 2016 [25]	Age ≥18yrs, triage category 1 or 2	Age <18yrs and TRI	62.0	49.4	502	28 days in-hospital mortality	MEWS	≥3	78.0	79.9	0.85	Poor
Maftoohian et al. 2020 [26]	Age ≥18yrs	Advance airway, CPR, intubation applied, not admitted, DOA	62.1	50.9	381	30 days in-hospital mortality	MEWS	≥3	78.3	68.4	0.73	Good
						30 days in-hospital mortality	MEWS	≥4	30.4	83.2	N/S
						ICU admission	MEWS	≥3	85.7	67.6	0.77
Yuan et al. 2018 [27]	Stay longer than 24 hours	Age < 14yrs, LOS less than 24 hours, incomplete information, lost follow up, non-cooperative family members	64.0	60.0	612	28 days in-hospital mortality	MEWS	≥4	56.9	79.4	0.72	Good
						ICU admission	MEWS	≥3	64.5	68.7	0.73
Dundar et al. 2016 [28]	Age ≥65yrs	Age < 65yrs and TRI patients, CPR	75.0	55.9	671	28 days in-hospital mortality	MEWS	≥4	74.0	89.0	0.89	Good
Graham et al. 2020 [29]	Age ≥18yrs with triage as Emergency or Urgent	Age <18yrs, pregnant, presenting out of research hours	72.0	50.9	1253	30 days in-hospital mortality	NEWS	≥5	35.8	86.8	0.61	Good