Table 5. Association between rise and fall of blood pressure and incident any stroke using different lag periods.
| Lag period (years) | n/N | Tertile 1 | Tertile 2 HR | Tertile 3 | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |||
| Systolic blood pressure | ||||||
| 3 | 541/7,241 | 1.54 (1.32–1.75) | <0.001 | 1 (ref) | 1.31 (1.09–1.52) | 0.01 |
| 6 | 212/4,862 | 2.07 (1.68–2.45) | <0.001 | 1 (ref) | 1.80 (1.43–2.18) | <0.001 |
| 9 | 118/1,593 | 2.16 (1.58–2.73) | 0.01 | 1 (ref) | 1.88 (1.32–2.43) | 0.03 |
| Diastolic blood pressure | ||||||
| 3 | 541/7,238 | 1.46 (1.25–1.67) | <0.001 | 1 (ref) | 1.00 (0.78–1.22) | 0.99 |
| 6 | 212/4,859 | 1.49 (1.14–1.84) | 0.03 | 1 (ref) | 1.19 (0.84–1.54) | 0.34 |
| 9 | 118/1,591 | 1.38 (0.89–1.87) | 0.19 | 1 (ref) | 1.12 (0.62–1.62) | 0.67 |
Values in bold are statistically significant. Adjusted for age, sex, mean systolic or diastolic blood pressure, and propensity score. CI, confidence interval; HR, hazard ratio; n, number of participants with incident any stroke; N, total number of participants at risk; ref, reference.