Table 1.
Baseline demographic and clinical characteristics of all vaccinated health-care workers and by matched subcohort, and for the matched unvaccinated populations
| All vaccinated health-care workers (N=477 102) |
Matched vaccinated health-care workers |
Matched unvaccinated individuals |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Scheme A and B (n=215 813) | Scheme A (n=99 084) | Scheme B (n=116 729) | Western Cape provincial dataset (n=19 951) | Scheme A and B (n=215 813) | Scheme A (n=99 084) | Scheme B (n=116 729) | Western Cape provicinal dataset (n=19 951) | |||
| Sex | ||||||||||
| Female | 357 401 (74·9%) | 165 452 (76·7%) | 72 093 (72·8%) | 93 359 (80·0%) | 14 641 (73·4%) | 165 452 (76·7%) | 72 093 (72·8%) | 93 359 (80·0%) | 14 641 (73·4%) | |
| Male | 119 701 (25·1%) | 50 362 (23·3%) | 26 992 (27·2%) | 23 370 (20·0%) | 5310 (26·6%) | 50 362 (23·3%) | 26 992 (27·2%) | 23 370 (20·0%) | 5310 (26·6%) | |
| Follow-up time, days | 109 (72·0–129·0) | 108·6 (71·3–128·3) | 108·7 (67·5–129·8) | 108·4 (74·2–126·6) | 72·1 (16·0–118·0) | 108·3 (71·1–128·1) | 108·1 (67·0–129·4) | 108·4 (74·4–126·6) | 72·0 (16·0–118·0) | |
| Age, years | ||||||||||
| Median | 42·0 (33·0–51·0) | 42·9 (35·0–51·4) | 39·7 (31·6–49·2) | 44·9 (37·8–52·6) | 41·0 (24·0–61·0) | 42·4 (34·6–50·9) | 39·2 (31·1–48·7) | 44·5 (37·4–52·2) | 41·0 (24·0–60·0) | |
| <18 | 0 | 0 | 0 | 0 | 0 | 48 (<0·1%) | 48 (<0·1%) | 0 | 0 | |
| 18–39 | 209 411 (43·9%) | 81 336 (37·7%) | 47 430 (47·9%) | 33 906 (29·1%) | 9089 (45·6%) | 84 529 (39·2%) | 48 884 (49·3%) | 35 645 (30·5%) | 9284 (46·5%) | |
| 40–49 | 136 967 (28·7%) | 67 746 (31·4%) | 26 499 (26·7%) | 41 247 (35·3%) | 5489 (27·5%) | 66 947 (31·0%) | 26 046 (26·3%) | 40 901 (35·0%) | 5353 (26·8%) | |
| 50–59 | 96 235 (20·2%) | 48 978 (22·7%) | 16 505 (16·7%) | 32 473 (27·8%) | 4593 (23·0%) | 48 157 (22·3%) | 16 073 (16·2%) | 32 084 (27·5%) | 4641 (23·3%) | |
| 60–69 | 29 181 (6·1%) | 15 678 (7·3%) | 6988 (7·1%) | 8690 (7·4%) | 780 (3·9%) | 14 222 (6·6%) | 6512 (6·6%) | 7710 (6·6%) | 673 (3·4%) | |
| 70–79 | 4698 (1·0%) | 1875 (0·9%) | 1492 (1·5%) | 383 (0·3%) | 0 | 1729 (0·8%) | 1368 (1·4%) | 361 (0·3%) | 0 | |
| ≥80 | 610 (0·1%) | 200 (0·1%) | 170 (0·2%) | 30 (<0·1%) | 0 | 181 (0·1%) | 153 (0·2%) | 28 (<0·1%) | 0 | |
| Geographical location | ||||||||||
| Eastern Cape | 57 673 (12·1%) | 20 163 (9·3%) | 5671 (5·7%) | 14 492 (12·4%) | .. | 19 482 (·09%) | 5384 (5·4%) | 14 098 (12·1%) | .. | |
| Free State | 24 182 (5·1%) | 11 276 (5·2%) | 3672 (3·7%) | 7604 (6·5%) | .. | 11 597 (5·4%) | 3733 (3·8%) | 7864 (6·7%) | .. | |
| Gauteng | 124 865 (26·2%) | 64 490 (29·9%) | 42 136 (42·5%) | 22 354 (19·2%) | .. | 66 465 (30·8%) | 43 498 (43·9%) | 22 967 (19·7%) | .. | |
| Kwazulu-Natal | 92 689 (19·4%) | 41 553 (19·3%) | 16 152 (16·3%) | 25 401 (21·8%) | .. | 40 944 (19·0%) | 15 939 (16·1%) | 25 005 (21·4%) | .. | |
| Limpopo | 33 222 (7·0%) | 16 051 (7·4%) | 1955 (2·0%) | 14 096 (12·1%) | .. | 16 028 (7·4%) | 2115 (2·1%) | 13 913 (11·9%) | .. | |
| Mpumalanga | 20 362 (4·3%) | 9115 (4·2%) | 2283 (2·3%) | 6832 (5·9%) | .. | 9393 (4·4%) | 2361 (2·4%) | 7032 (6·0%) | .. | |
| North West | 23 046 (4·8%) | 10 650 (4·9%) | 2253 (2·3%) | 8397 (7·2%) | .. | 11 225 (5·2%) | 2407 (2·4%) | 8818 (7·6%) | .. | |
| Northern Cape | 9343 (2·0%) | 2999 (1·4%) | 834 (0·8%) | 2165 (1·9%) | .. | 3117 (1·4%) | 863 (0·9%) | 2254 (1·9%) | .. | |
| Western Cape | 91 720 (19·2%) | 38 839 (18·0%) | 23 451 (23·7%) | 15 388 (13·2%) | 19 951 (100%) | 36 881 (17·1%) | 22 103 (22·3%) | 14 778 (12·7%) | 19 951 (100%) | |
| Unallocated | 0 | 678 (0·3%) | 678 (0·7%) | 0 | 0 | 681 (0·3%) | 681 (0·7%) | 0 | 0 | |
| Number of risk factors for severe COVID-19 | ||||||||||
| 0 | .. | 141 692 (65·7%) | 66 741 (67·4%) | 74 951 (64·2%) | .. | 141 692 (65·7%) | 66 741 (67·4%) | 74 951 (64·2%) | .. | |
| 1 | .. | 54 548 (25·3%) | 24 495 (24·7%) | 30 053 (25·8%) | .. | 54 548 (25·3%) | 24 495 (24·7%) | 30 053 (25·7%) | .. | |
| 2 | .. | 16 041 (7·4%) | 6200 (6·3%) | 9841 (8·4%) | .. | 16 041 (7·4%) | 6200 (6·3%) | 9841 (8·4%) | .. | |
| ≥3 | .. | 3533 (1·6%) | 1649 (1·7%) | 1884 (1·6%) | .. | 3533 (1·6%) | 1649 (1·7%) | 1884 (1·6%) | .. | |
| Risk factors for severe COVID-19 | ||||||||||
| Diabetes | 28 058 (5·9%) | 13 012 (6·0%) | 4207 (4·2%) | 8805 (7·5%) | 12 306 (5·7%) | 4281 (4·3%) | 8025 (6·9%) | |||
| Hypertension | 74 370 (15·6%) | 32 768 (15·2%) | 12 421 (12·5%) | 20 347 (17·4%) | .. | 33 266 (15·4%) | 12 508 (12·6%) | 20 758 (17·8%) | .. | |
| HIV | 39 383 (8·3%) | 23 752 (11·0%) | 4720 (4·8%) | 19 032 (16·3%) | .. | 22 148 (10·3%) | 3537 (3·6%) | 18 611 (15·9%) | .. | |
| Cardiovascular disease | 3430 (0·7%) | 2360 (1·1%) | 1343 (1·4%) | 1017 (0·9%) | .. | 2405 (1·1%) | 1394 (1·4%) | 1011 (0·9%) | .. | |
| Chronic liver disease | .. | 282 (0·1%) | 280 (0·3%) | 2 (<0·1%) | 275 (0·1%) | 273 (0·3%) | 2 (<0·1%) | |||
| Chronic renal disease | .. | 278 (0·1%) | 154 (0·2%) | 124 (0·1%) | .. | 380 (0·2%) | 221 (0·2%) | 159 (0·1%) | .. | |
| Cancer | 1364 (0·3%) | 1673 (0·8%) | 909 (0·9%) | 764 (0·7%) | .. | 1882 (0·9%) | 1017 (1·0%) | 865 (0·7%) | .. | |
| Chronic respiratory disease | 1733 (0·4%) | 7905 (3·7%) | 5244 (5·3%) | 2661 (2·3%) | .. | 7701 (3·6%) | 4762 (4·8%) | 2939 (2·5%) | .. | |
| Neurological disorders | .. | 1463 (0·7%) | 870 (0·9%) | 593 (0·5%) | .. | 1986 (0·9%) | 1197 (1·2%) | 789 (0·7%) | .. | |
| Overweight or obesity | .. | 11 058 (5·1%) | 10 080 (10·2%) | 978 (0·8%) | 11 244 (5·2%) | 10 312 (10·4%) | 932 (0·8%) | |||
| Severe mental disorders | .. | 2700 (1·3%) | 1958 (2·0%) | 742 (0·6%) | .. | 3633 (1·7%) | 2621 (2·6%) | 1012 (0·9%) | .. | |
| Solid organ transplant recipient | .. | 50 (<0·1%) | 50 (0·1%) | 0 | .. | 50 (<0·1%) | 50 (0·1%) | 0 | .. | |
| History of COVID-19* | ||||||||||
| Ever had a COVID-19 test | .. | 129 655 (60·1%) | 88 691 (89·5%) | 40 964 (35·1%) | 11 886 (59·6%) | 133 238 (61·7%) | 88 691 (89·5%) | 44 547 (38·2%) | 11 886 (59·6%) | |
| Documented previous SARS-CoV-2 infection (wave 1)† | .. | 13 742 (6·4%) | 5666 (5·7%) | 8076 (6·9%) | 2692 (13·5%) | 12 792 (5·9%) | 5616 (5·7%) | 7176 (6·1%) | 1446 (7·2%) | |
| Documented previous SARS-CoV-2 infection (wave 2) | .. | 9780 (4·5%) | 4727 (4·8%) | 5053 (4·3%) | 2030 (10·2%) | 10 837 (5%) | 4777 (4·8%) | 6060 (5·2%) | 1169 (5·9%) | |
Data are n (%) or median (IQR).
*
Before date of vaccination or matching.
†
Infection before Oct 1, 2020.