Table 1.
Ffar4 signalling pathway gene expression in WT and Ffar4KO cardiac myocytes 3-day post-TAC
| Gene | Gene name | WT | Ffar4KO |
|---|---|---|---|
| Proximal signalling | Fold change | ||
| Arrb2 | βArestin2 | 2.48 | |
| Rgs3 | Regulator of G-protein signalling 3 | −1.77 | |
| Prkcb | Protein kinase Cb | 2.11 | |
| Prkcd | Protein kinase Cd | 2.08 | 2.79 |
| Prkcq | Protein kinase Cq | −3.79 | |
| Prkd1 | Protein kinase D1 | −1.97 | |
| Inflammatory signalling | |||
| Nfkb2 | NFkB2 | 1.87 | |
| Nfkbie | Ikb-e (NFkb inhibitor, epsilon) | 5.08 | |
| Nfkbiz | Ikb-z (NFkb inhibitor, zeta) | 3.25 | |
| Mapk10 | Jnk3 (mitogen activated protein kinase 10) | −1.83 | −1.81 |
| cPLA2a-oxylipin production | |||
| Pla2g4a | Cytoplasmic phospholipase A2a | 2.79 | |
| Alox5 | Arachidonate 5-lipoxygenase | −1.77 | |
| Alox5ap | Arachidonate 5-lipoxygenase activating protein | 4.29 | |
| Ptgs2 | Prostaglandin-endoperoxide synthase 2 (cyclooxygenase 2) | 7.15 | |
| Cyp2u1 | Cytochrome P450, family 2, subfamily u, polypeptide 1 | −1.86 | |
| Cyp4b1 | Cytochrome P450, family 4, subfamily b, polypeptide 1 | −1.80 | |
| cPLA2α/IGF hypertrophy | |||
| Akt2 | Akt2, PKBb | −1.85 | |
| Igf1 | Insulin-like growth factor 1 | 2.79 | |
| Pak1 | PAK1 (p21 (RAC1) activated kinase 1) | 6.59 | |
| Pi3kcd | p110d (phospatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta) | 2.34 | |
| Pi3kcg | p110g (phospatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma) | 3.24 | |
| Pi3kr1 | p85a (phospatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit alpha) | −7.46 | |
| Pi3kr5 | Phospatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit 5 | 10.22 | |
| Oxidation-reduction | |||
| Hmox1 | Haeme oxygenase-1 | 24.04 | |
| Pla2g4a | Cytoplasmic phospholipase A2a | 2.79 | |