Table 2.
Genetic inhibition of FFAR4 (FFAR4 R270H) is associated with eccentric remodelling in humans
| Overall |
Males |
Females |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Phenotype | Beta [95% CI] | n | P value | Beta [95% CI] | n | P value | Beta [95% CI] | n | P value |
| LV mass max (g) | 10.9 [1.9, 19.9] | 6402 | 0.02 | 20.4 [5.2, 35.6] | 3182 | 0.009 | 3.0 [−7.2, 13.2] | 3220 | 0.56 |
| LVIDd max (mm) | 1.25 [1.2, 0.5] | 6969 | 0.01 | 2.8 [1.2, 4.5] | 3357 | <0.001 | −0.0004 [−1.2, 1.1] | 3612 | 0.99 |
| LA diam max (mm) | 1.48 [0.5, 2.5] | 6894 | 0.004 | 2.4 [0.74, 4.1] | 3337 | 0.005 | 0.80 [−2.0, 0.4] | 3557 | 0.20 |
| EF min (%) | −0.96 [−2.4, 0.5] | 6964 | 0.19 | −2.3 [−0.17, 4.8] | 3559 | 0.07 | 0.13 [−1.5, 1.7] | 3605 | 0.87 |
EF min, ejection fraction minimum; LA diam, left atrial diameter; LV mass max, left ventricular mass maximum; LVIDd, left ventricular internal dimension during diastole. Bold values indicate statistical significance.