Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 20;118(4):1115–1125. doi: 10.1093/cvr/cvab139

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The histone neutralizing agent mCBS reduces infarct size in an ex vivo rat heart model of ischaemic and reperfusion injury (I/R). (A) Infarct size in hearts exposed to 45 min of global ischaemia followed by 2 h reperfusion, in the presence of vehicle or 100 μg/mL mCBS or pre-treated with ischaemic preconditioning (IPC). N = 6 hearts per treatment group. (B) The concentration of free histone H4 in the perfusate of rat hearts at the point of reperfusion after 45 min of ischaemia, measured by DELFIA. N = 6 (or 4 IPC) hearts per group. Statistical analyses by one-way ANOVA with Tukey post-test. *P < 0.05, ***P < 0.001.