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. 2021 Apr 20;118(4):1115–1125. doi: 10.1093/cvr/cvab139

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© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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In an in vivo rat model of ischaemic and reperfusion injury, the histone-H4 specific neutralizing peptide HIPe, but not mCBS, reduced infarct size. (A) Infarct size as a percentage of area at risk (AAR) in an in-vivo rat coronary artery occlusion model of I/R, after administration of vehicle or mCBS. N = 4–7 hearts per group. (B) Infarct size as a percentage of AAR in an in-vivo rat coronary artery occlusion model of I/R, after administration of vehicle or HIPe. N = 6–7 hearts per group. Statistical analyses by one-way ANOVA with Tukey post-test (C), or unpaired T-test (D). **P < 0.01, ***P < 0.001.