Table 2.
Clinical trials involving autophagy in the cardiovascular system
| Name of the study | Study type | Description | Clinical trial identifier |
|---|---|---|---|
| MUcociliary Clearance IN Stroke (MUCINS) | Observational | Evaluation of autophagy in respiratory tissue (nasal, tracheal, and bronchial) | NCT03884166 |
| Transforming Growth Factor Beta Signalling in the Development of Muscle Weakness in Pulmonary Arterial Hypertension | Observational | Determination of the contribution of atrophy and autophagy to muscle wasting in PAH | NCT01847716 |
| Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease (INTERCEDE) | Interventional | Evaluation among PAD participants whether intermittent pneumatic compression therapy combined with exercise improves autophagy (LC3, LAMP2, PRKN) at 6-month follow-up, compared to exercise alone | NCT03871075 |
| Autophagy and Venous Endothelial Function | Observational | Evaluation of endothelial function in venous samples from patients with venous insufficiency before and after treatment with autophagy enhancer spermidine | NCT04138134 |
| Autophagy Maintains Vascular Function Through a Novel Glycolysis-linked Pathway Regulating eNOS | Interventional | Evaluation of BECN1, ATG3, ATG5, ATG7, LAMP1, LAMP2, and SQSTM1 after rhythmic handgrip exercise or chronic exercise training | NCT04200560 |
| Autophagy, Oxidative Stress, and Hippo Signalling in Human Aortic Aneurysm | Observational | Comparison between the levels of STK3–STK4 (HIPPO) signalling and autophagy markers observed in aortic aneurysms and the levels assessed in the adjacent non-aneurysmatic aortic portions | NCT03211000 |
| Effects of Trehalose and Polyphenols in Vasculopathic Patients | Interventional | Change of autophagy (LC3) in PAD patients after mixed supplementation of trehalose and polyphenols | NCT04061070 |
| Effect of Hydroxychloroquine on Atrial Fibrillation Recurrence | Interventional | Recurrence rate of atrial fibrillation after radiofrequency catheter ablation, anticoagulant therapy, and hydrochloroquine treatment (200 mg, bidpo) | NCT03592823 |
| Potential Impact of Neuroimmune and Autophagic Alterations on the Progression and Severity of Human Atherosclerotic Process | Observational | Characterization of the autophagic process and correlation with neural modulations of the stability/instability plaque | NCT03922698 |
PAD, peripheral arterial disease; PAH, pulmonary arterial hypertension.