Table 1.
Basic clinical characteristics of enrolled patients classified by serum CTRP9 level.
| CTRP9 | Total (n = 206) | T1 (n = 69) | T2 (n = 69) | T3 (n = 68) | P values |
|---|---|---|---|---|---|
| (T1 ≤ 1.23) | (1.23 < T2 < 1.36) | (T3 ≥ 1.36) | |||
| Demographic data | |||||
| Age (years) | 57.24 ± 9.37 | 55.87 ± 9.98 | 58.45 ± 9.24 | 57.41 ± 8.81 | 0.267 |
| Male sex, n (%) | 174 (84.5%) | 58 (84.1%) | 56 (81.2%) | 60 (88.2%) | 0.517 |
| BMI (kg/m2) | 26.55 ± 3.00 | 26.21 ± 2.95 | 26.49 ± 3.05 | 26.94 ± 3.00 | 0.384 |
| SBP (mmHg) | 137.64 ± 17.46 | 136.36 ± 16.72 | 138.25 ± 17.83 | 138.31 ± 18.00 | 0.760 |
| DBP (mmHg) | 80.78 ± 10.13 | 80.86 ± 9.43 | 80.64 ± 9.81 | 80.84 ± 11.23 | 0.990 |
| HR (bpm) | 72.59 ± 8.87 | 71.87 ± 7.94 | 72.84 ± 9.28 | 73.07 ± 9.40 | 0.702 |
| Alcohol use, n (%) | 48 (23.3%) | 19 (27.5%) | 14 (20.3%) | 15 (22.1%) | 0.577 |
| Current smokers, n (%) | 83 (40.3%) | 27 (39.1%) | 26 (37.7%) | 30 (44.1%) | 0.723 |
| Types of CAD | |||||
| UAP, n (%) | 135 (65.5%) | 52 (75.4%) | 42 (60.9%) | 41 (60.3%) | 0.108 |
| SAP, n (%) | 71 (34.5%) | 17 (24.6%) | 27 (39.1%) | 27 (39.7%) | 0.108 |
| Medical history | |||||
| Hypertension, n (%) | 132 (64.1%) | 47 (68.1%) | 44 (63.8%) | 41 (60.3%) | 0.633 |
| T2DM, n (%) | 35 (17.0%) | 1 (1.4%) | 10 (14.5%) | 24 (35.3%) | <0.001∗ |
| Hyperlipidemia, n (%) | 171 (83.0%) | 55 (79.7%) | 53 (76.8%) | 63 (92.6%) | 0.032∗ |
| MetS, n (%) | 109 (52.9%) | 30 (43.5%) | 35 (50.7%) | 44 (64.7%) | 0.041∗ |
| Laboratory measurement | |||||
| MONO | 0.38 ± 0.13 | 0.40 ± 0.13 | 0.38 ± 0.13 | 0.36 ± 0.11 | 0.226 |
| eGFR | 95.54 ± 14.88 | 95.65 ± 14.29 | 92.84 ± 16.56 | 98.18 ± 13.31 | 0.110 |
| CREA, mmol/L | 74.09 ± 15.29 | 74.88 ± 14.90 | 75.43 ± 17.13 | 71.94 ± 13.60 | 0.359 |
| UREA, mmol/L | 5.03 ± 1.31 | 5.03 ± 1.30 | 5.22 ± 1.22 | 4.85 ± 1.40 | 0.251 |
| UA, mmol/L | 353.32 ± 91.67 | 355.06 ± 97.98 | 364.23 ± 95.65 | 340.49 ± 79.95 | 0.313 |
| FBG, mmol/L | 5.36 (4.92-6.22) | 5.36 (5.01-6.09) | 5.49 (4.95-6.32) | 5.23 (4.77-6.35) | 0.684 |
| TC, mmol/L | 4.25 ± 1.18 | 4.21 ± 0.99 | 4.32 ± 1.27 | 4.23 ± 1.29 | 0.839 |
| TG, mmol/L | 1.52 (1.13-2.13) | 1.49 (1.07-2.19) | 1.53 (1.07-2.03) | 1.55 (1.18-2.21) | 0.738 |
| HDL-C, mmol/L | 1.01 ± 0.22 | 1.04 ± 0.23 | 1.05 ± 0.25 | 0.96 ± 0.16 | 0.030∗ |
| LDL-C, mmol/L | 2.46 ± 1.01 | 2.38 ± 0.82 | 2.49 ± 1.08 | 2.51 ± 1.12 | 0.703 |
| Non-HDL-C, mmol/L | 3.23 ± 1.14 | 3.17 ± 0.97 | 3.27 ± 1.21 | 3.25 ± 1.25 | 0.822 |
| Hs-CRP | 1.18 (0.65-2.47) | 1.29 (0.61-2.91) | 1.13 (0.71-2.52) | 1.12 (0.66-2.02) | 0.811 |
| Cardiovascular medications | |||||
| Antiplatelet agents, n (%) | 175 (85.0%) | 61 (88.4%) | 59 (85.5%) | 55 (80.9%) | 0.425 |
| ACEI/ARB, n (%) | 52 (25.2%) | 18 (26.1%) | 13 (18.8%) | 21 (30.9%) | 0.284 |
| CCB, n (%) | 64 (31.1%) | 26 (37.7%) | 21 (30.4%) | 17 (25.0%) | 0.277 |
| β receptor blocker, n (%) | 98 (47.6%) | 37 (53.6%) | 32 (46.4%) | 29 (42.6%) | 0.433 |
| Nitrates, n (%) | 106 (51.5%) | 43 (62.3%) | 33 (47.8%) | 30 (44.1%) | 0.084 |
| Statins, n (%) | 148 (71.8%) | 53 (76.8%) | 50 (72.5%) | 45 (66.2%) | 0.364 |
| Coronary angiography data | |||||
| SYNTAX score | 17.91 ± 7.87 | 19.18 ± 8.07 | 16.42 ± 6.91 | 17.99 ± 8.45 | 0.119 |
| Number of the diseased vessels | 0.644 | ||||
| One-vessel disease, n (%) | 42 (20.4%) | 12 (17.4%) | 13 (18.8%) | 17 (25.0%) | 0.503 |
| Two-vessel disease, n (%) | 62 (30.1%) | 19 (27.5%) | 24 (34.8%) | 19 (27.9%) | 0.581 |
| Three-vessel disease, n (%) | 102 (49.5%) | 38 (55.1%) | 32 (46.4%) | 32 (47.1%) | 0.525 |
| CTO lesions, n (%) | 104 (50.5%) | 27 (39.1%) | 39 (56.5%) | 38 (55.9%) | 0.069 |
| Location of the diseased artery | 0.353 | ||||
| RCA, n (%) | 98 (47.6%) | 32 (46.4%) | 29 (42.0%) | 37 (54.4%) | 0.339 |
| LCX, n (%) | 35 (17.0%) | 9 (13.0%) | 13 (18.8%) | 13 (19.1%) | 0.563 |
| LAD, n (%) | 73 (35.4%) | 28 (40.6%) | 27 (39.1%) | 18 (26.5%) | 0.165 |
∗ indicated the differences between groups were statistically significant. Abbreviations: CTRP9: C1q/tumor necrosis factor-related protein 9; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HR: heart rate; CAD: coronary artery disease; UAP: unstable angina pectoris; SAP: stable angina pectoris; T2DM: type II diabetes mellitus; MetS: metabolic syndrome; MONO: monocyte count; eGFR: estimated glomerular filtration rate; CREA: creatinine; UREA: urea; UA: uric acid; FBG: fasting blood glucose; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; Hs-CRP: high sensitivity C-reactive protein; ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker; CCB: calcium channel blocker; CTO: chronic total occlusion; RCA: right coronary artery; LCX: left circumflex artery; LAD: left anterior descending artery.