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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Trends Neurosci. 2022 Apr;45(4):312–322. doi: 10.1016/j.tins.2022.01.005

Figure 3. Metabolite transfer at mitochondria-lysosome contact sites.

Figure 3.

Mitochondria-lysosome contact sites can mediate the exchange of metabolites, such as calcium, cholesterol and iron. The transport of calcium from lysosomes to mitochondria occurs via the lysosomal membrane channel TRPML1 which promotes efflux of lysosomal calcium into the mitochondrial matrix via the outer and inner mitochondrial membrane channels VDAC1 and MCU at mitochondria-lysosome contacts. Cholesterol and iron have also been shown to be transferred from lysosomes to mitochondria at contact sites.