. Author manuscript; available in PMC: 2023 Apr 1.

Published in final edited form as: Trends Neurosci. 2022 Apr;45(4):312–322. doi: 10.1016/j.tins.2022.01.005

Table 1.

Genetic mutations associated with neurodegenerative diseases that have been linked to misregulation of mitochondria-lysosome contacts.

Neurodegenerative Disease	Description	Disease Gene	References
Charcot-Marie-Tooth Disease	Peripheral neuropathy	MFN2 (Charcot-Marie-Tooth Type 2A)	[16]
		RAB7 (Charcot-Marie-Tooth Type 2B)	[2, 8]
		GDAP1 (Charcot-Marie-Tooth Type 2K)	[9]
Parkinson’s Disease	Movement disorder	GBA (Parkinson’s disease)	[64]
Parkinson’s Disease	Movement disorder	PINK1 (Parkinson’s disease)	[65]
Lysosomal Storage Disorders	Multi-systemic/neurodegeneration	TRPML1 (Mucolipidosis Type IV)	[37]
Lysosomal Storage Disorders	Multi-systemic/neurodegeneration	NPC1 (Niemann-Pick Type C)	[38]