Host genetics associated with high Prevotella abundance. (A) Regional association plot for the GWAS of high Prevotella abundance. Linkage disequilibrium (LD) was based on the admixed American population from 1000 Genomes. Genotype frequencies for rs3769502 and rs7573751 are shown [MXL: subjects with Mexican ancestry in Los Angeles, California; EUR: Europeans, from 1000 Genomes]. (B,E) Prevotella abundance by rs3769502 and rs7573751 genotypes. Bars represent the median and interquartile range; error bars show the minimum and maximum abundances. (C,F) % of subjects with high and low Prevotella abundance by rs3769502 and rs7573751 genotypes. (D,G) Forest plots showing the association between rs3769502 and rs7573751 GA/AA and AA genotypes and high Prevotella abundance. OR: odds ratio; AOR: OR adjusted for age, gender and presence of liver fibrosis.