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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Pflugers Arch. 2022 Jan 20;474(4):397–403. doi: 10.1007/s00424-021-02653-9

Figure 1. Blockade of Slc7a5 with JPH203 alleviates neuropathic pain in the SNI rodent model.

Figure 1.

Alleviation of neuropathic pain in rats (two weeks after SNI) following intrathecal injection (n=5 per group, ****p<0.0001, 2-way ANOVA) of the Slc7a5 blocker, JPH203. At peak anti-allodynic effect at 180 min post-injection, paw withdrawal threshold values were Control: 3.53 ± 0.344 g and JPH203: 14.4 ± 0.65 g. Inset indicates the area under the curve (AUC) derived using GraphPad Prism. Red arrow indicates time of JPH203 injection. Experimenter was blinded to the treatment condition.