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. Author manuscript; available in PMC: 2023 Mar 16.
Published in final edited form as: Neuron. 2022 Jan 18;110(6):1068–1083.e5. doi: 10.1016/j.neuron.2021.12.027

Figure 8. SST-mGlu5−/− mice display specific alterations in cognitive behaviors.

Figure 8.

(A) Mice underwent 20 minutes acute restraint stress immediately prior to testing cognitive and motivational behaviors. (B) In control mice, stress decreased the percent of correct alternations in the Y-maze task. SST-mGlU5−/− mice displayed normal performance under control conditions and were not impaired by acute stress. (Two-way ANOVA stress x KO interaction: F1,38=2.5, p<0.12; main effect of stress: F1,38=6.1, p<0.02; *:p<0.02, Sidak test). N=10-12 mice. (C) Mice performed holepokes in an operant chamber to obtain liquid food reinforcement on a progressive ratio schedule. Acute restraint stress decreased the number of rewards earned, but no effect of genotype or interaction was observed. (RM Two-way ANOVA stress x KO interaction: F2,26=0.9, n.s.; main effect of stress: F2,26=7.6, p<0.01; *:p<0.02, **:p<0.01 Sidak test). N=6-9. (D) SST-mGlU5−/− mice trended towards decreased tone-related freezing on the conditioning day. (RM Two-way ANOVA tone x KO interaction: F5,85=1.9, p<0.1; main effect of KO: F1,17=2.7, p<0.12; $:p<0.053, Sidak test). N=9-10. (E) One day after conditioning, SST-mGlu5−/− mice displayed decreased recall of cued freezing. (25.9±6.0 vs 52.8±9.7%; t17=2.41; *:p<0.03, t-test). N=9-10. (F) WT and SST-mGlU5−/− mice did not differ in performance during an operant discrimination task reinforced by sucrose delivery (RM Two-way ANOVA session x KO interaction: F9,81=1.0, n.s.; main effect of KO: F1,9<0.01, n.s.). N=5-6.