Table 1.

Selected peptide sequences for targeting the tumor microenvironment

Peptide	Sequence	Molecular target	Cellular target	References
RGD	RGDa	Integrin αvβ3, αvβ5	Tumor cells, tumor vasculature	(Ruoslahti and Pierschbacher, 1986)
iRGD	CRGDK/RGPD/EC	Integrin αvβ3, αvβ5	Tumor cells, tumor vasculature	(Sugahara et al., 2009; Sugahara et al., 2010)
C7 peptide	MHTAPGWGYRLS	Folate receptor α	Tumor cells	(Xing et al., 2018)
PH1	TMGFTAPRFPHY	Tie2	Tumor neovascular endothelial cells	(Mai et al., 2009)
UNO	CSPGAKVRC	CD206/MRC1	M2 tumor-associated macrophages	(Scodeller et al., 2017)
mUNO	CSPGAK	CD206/MRC1	M2 tumor-associated macrophages	(Scodeller et al., 2017)
P-D2	GGVTLTYQFAAGPRDK	CD11c	Dendritic cells	(Lewis et al., 2012)

^aThe main binding domain is displayed.