. Author manuscript; available in PMC: 2023 Mar 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2022 Feb 25;15(3):e010636. doi: 10.1161/CIRCEP.121.010636

Table 3:

Natriuretic peptides: Significant effects on ionic currents

	I_Na^§	Late-I_Na^§	I_Ca,L^‡	I_K1^§	I_Kv1.5^∥	I_To^§
	pA/pF	pA/pF	pA/pF	pA/pF	pA/pF	pA/pF
Control	−72.3±4.9	0.27±0.01	−47.0±5.4	−76.0±9.5	4.3±0.7	42.5±2.9
ANP oligo	−47.1±3.1^*	0.22±0.01^*	−31.7±3.8^*	−45.9±5.9^*	7.1±0.7^*	47.1±3.1^*
Control	−59.0±4.7	0.24±0.004	−28.9±3.9	−96.4±15	12.3±1.5	46.5±3.2
mutANP	−42.7±3.2^*	0.20±0.002^†	−18.1±2.5^†	−58.2±9.0^*	13.3±1.7^*	54.3±3.5^*
Control	−59.6±6.0	0.23±0.004	−59.3±7.5	−88.4±7.8	15.3±2.5	48.5±3.2
mutANP oligo	−39.2±4.4^*	0.17±0.004^†	−34.5±3.0^†	−54.8±5.8^*	18.9±3.1^*	70.1±4.6^*
Control	−50.5±3.0	0.32±0.004	−38.0±2.2	−101.7±6.6	17.3±2.6	43.8±1.6
BNP oligomer	−36.5±2.6^*	0.22±0.003^†	−46.7±3.3^*	−80.5±6.8^*	22.2±3.5^*	51.5±1.9^*

oligo represents oligomer

P<0.05

^†

P<0.01

^‡

mouse atrial cells (n=3 mice for each group; n=7-15)

^§

HL-1 cells (n=7-16)

^∥

Ltk⁻ cells (n=7-13)