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. 2022 Mar 10;29(3):190–193. doi: 10.1038/s41594-022-00729-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, Superposition of five AlphaFold2 models of the GP2 N-terminal branch indicates the presence of three distinct units, with a central hairpin-like region (residues D45-F60; orange box) separating an N-terminal low-confidence region (residues V29-L44; red box) from a C-terminal globular domain (residues D61-S181; green box). An ensemble corresponding to the latter was used as search model for MR. b-c, Electron density for an Endo H cleavage-derived N-acetylglucosamine residue attached to N122 (b) and the hairpin region (c), two GP2 elements not included in the MR search ensemble. Fourier maps at different stages of the structure determination process are shown, contoured at the indicated levels.