Extended Data Fig. 9. Switch regions are required for seipin function.

(a) Sequence alignment of seipin sequences from different species shows conserved F₂₃₂xxGLR sequence motif. Identical residues are colored in red boxes, red characters and blue framed residues indicate similarity in a group or across groups, respectively. (b) Western blot analysis of whole cell lysates from strains expressing indicated switch mutants or WT seipin under control of the PGK1 promoter with C-terminal 13xmyc tag.

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