Fig. 2.
The minimum mutation frequency to access n-SNP clique from the reference genome. A, B, and C illustrated the formation of 2, 3, and n-SNP cliques with minimum mutation. Each block represents the alleles at the SNP loci. The yellow blocks (shown with “R”) and the red blocks (shown with “A”) represent major and minor alleles, respectively. The circles with numbers exhibit the loci of the alleles in the reference genome. n represents the size of the maximal clique of the SNP coexistence network. Kn stands for the number of mutations required to form n-clique from the reference genome. From the plot, we concluded that the reference genome experienced at least 2n − 1 mutations to obtain an n-SNP clique. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)