Table 2.
List of mutations based on consensus sequences of the five pediatric cases.
| Genome Position | Gene | Ref.a | Case | Type of mutationb | Amino acid change | ||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||||
| 241 | 5' UTR | C | T | T | T | T | T | S | |
| 1454 | nsp2 | C | G | G | G | G | G | NS | L → V |
| 1613 | C | C | A | C | A | C | NS | L → I | |
| 3004 | nsp3 | G | T | T | T | T | T | NS | E → D |
| 3037 | C | T | T | T | T | T | S | ||
| 4921 | N | N | N | N | T | N | InDel | L → F, premature stop | |
| 6778 | T | C | C | C | C | C | S | ||
| 9209 | nsp4 | G | G | C | G | G | G | S | |
| 9483 | A | A | A | A | T | A | S | ||
| 9565 | C | T | C | T | T | T | S | ||
| 11288 | nsp6 | T | N | N | N | N | N | InDel | |
| 11289 | C | N | N | N | N | N | InDel | ||
| 11290 | T | N | N | N | N | N | InDel | ||
| 11291 | G | N | N | N | N | N | InDel | ||
| 11292 | G | N | N | N | N | N | InDel | ||
| 11293 | T | N | N | N | N | N | InDel | ||
| 11294 | T | N | N | N | N | N | InDel | ||
| 11295 | T | N | N | N | N | N | InDel | ||
| 11296 | T | N | N | N | N | N | InDel | ||
| 14120 | RdRP | C | T | T | T | T | T | NS | P → L |
| 14408 | C | T | T | T | T | T | NS | P → L | |
| 17421 | nsp13 | C | T | T | T | T | T | S | |
| 18315 | nsp14 | G | A | A | A | A | A | S | |
| 18877 | C | T | T | T | T | T | S | ||
| 21597 | S | C | T | T | T | T | T | NS | S → F |
| 21794 | A | A | A | A | G | A | NS | R → G | |
| 22323 | C | T | C | C | Gap | C | NS | S → F | |
| 23403 | A | G | G | G | G | G | NS | D → G | |
| 23929 | C | C | C | T | C | C | S | ||
| 25563 | ORF3a | G | T | T | T | T | T | NS | Q → H |
| 25855 | G | C | C | C | C | C | NS | D → H | |
| 26051 | G | T | T | T | T | T | NS | S → I | |
| 26456 | E | C | T | C | C | C | C | NS | P → L |
| 26681 | M | C | T | T | T | T | T | NS | P → S |
| 26735 | C | T | T | T | T | T | NS | Q → Stop | |
| 27870 | ORF7b | G | T | T | T | T | T | NS | Stop → E |
| 28887 | N | C | T | T | T | T | T | NS | T → I |
| 29311 | C | T | T | T | T | T | S | ||
| 29754 | 3'UTR | C | T | Gap | T | Gap | T | S | |
a
Ref.: Reference genome (Wuhan Hu1).
b
NS, non-synonymous; S, synonymous; InDel, insertion/deletion. The bold values indicated to highlight value differences.