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. 2022 Mar 4;16:831061. doi: 10.3389/fncel.2022.831061

FIGURE 4.

FIGURE 4

Effects of saline, L-THA, TFB-TBOA, and TFB-TBOA with L-THA on arteriole diameter. Saline, L-THA (100 μM), TFB-TBOA (2 μM), or a combination of TFB-TBOA with L-THA were picospritzed near cortical arterioles. (A) Natural log (ln)-transformed raw data are presented as boxplots, using the mean of repeated measures from each animal. Raw values are from dilations (positive values), however, as data are ln-transformed, values > 1 are positive while values between 0 and 1 will appear on this scale as negative values (B,C) forest plots are included to visualize the results of the model and show the mean differences expressed as ratios of the effect observed with L-THA over that observed with saline (B) or TFB-TBOA with L-THA over that observed with L-THA (C). The redline is at 1 and represents no difference. The data for saline are from 6 animals (3 males, 3 females) and are the same data as that presented in Figures 1, 5–9, the data for L-THA are from 12 animals (7 males, 5 females) and are also the same as those presented in Figures 5–9. The data for TFB-TBOA are from 4 animals (2 males, 2 females) and the data for TFB-TBOA with L-THA are from 5 animals (3 males, 2 females).