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. 2022 Mar 4;16:831061. doi: 10.3389/fncel.2022.831061

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Copyright © 2022 Jackson, Krizman, Takano, Lee, Choi, Putt and Robinson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of saline, L-THA, L-NPA, Indomethacin, and L-NPA or Indomethacin with L-THA on arteriole diameter. Saline, L-THA (100 μM), L-NPA (2 μM), Indomethacin (10 μM), or a combination of NPA or Indomethacin with L-THA were picospritzed near cortical arterioles. (A) Data are presented as boxplots. Forest plots are also included to show the mean differences expressed as ratios of the effect observed with NPA with L-THA (B) or Indomethacin with L-THA (C) over that observed with L-THA. The redline is at 1 and represents no difference. The data for saline and L-THA are described in Figure 4 legend, the data for NPA are from 5 animals (4 males, 1 female), the data for NPA with L-THA are from 5 animals (3 males, 2 females), the data from Indomethacin are from 8 animals (3 males, 5 females) and the data for Indomethacin with L-THA are from 6 animals (3 males, 3 females).