TABLE 2.

Individual pulses – Area under the curve¹.

Contrast	Pulse	Difference (natural log scale)			Ratio
		Mean2	SE3	P-value4	Estimate5	95% CI6
						Lower	Upper
DMSO to Saline	1	1.632	0.809	0.046	5.116	1.030	25.400
	2	–0.382	0.831	0.647	0.682	0.132	3.540
	3	0.658	0.858	0.445	1.931	0.354	10.550
L-THA to Saline	1	2.062	0.691	0.003	7.860	2.003	30.836
	2	0.698	0.691	0.314	2.009	0.512	7.885
	3	2.465	0.702	0.001	11.763	2.934	47.154
TFB-TBOA to Saline	1	1.401	0.844	0.100	4.059	0.761	21.650
	2	0.316	0.846	0.710	1.371	0.256	7.335
	3	1.278	0.852	0.137	3.588	0.662	19.438
TFB-TBOA + L-THA to Saline	1	–0.016	0.803	0.984	0.984	0.200	4.833
	2	0.106	0.805	0.895	1.112	0.226	5.484
	3	0.364	0.815	0.656	1.440	0.286	7.238
TFB-TBOA + L-THA to L-THA	1	–2.078	0.693	0.003	0.125	0.032	0.495
	2	–0.591	0.693	0.395	0.554	0.140	2.188
	3	–2.101	0.705	0.004	0.122	0.030	0.494
Receptor Ant. to Saline	1	1.123	0.933	0.231	3.073	0.484	19.510
	2	0.392	0.935	0.676	1.480	0.232	9.440
	3	–0.762	0.995	0.445	0.467	0.065	3.340
Receptor Ant. + L-THA to Saline	1	2.722	0.862	0.002	15.209	2.759	83.830
	2	–0.118	0.862	0.892	0.889	0.161	4.910
	3	1.763	0.844	0.039	5.831	1.093	31.100
Receptor Ant. + L-THA to L-THA	1	0.660	0.760	0.387	1.935	0.429	8.720
	2	–0.816	0.759	0.285	0.442	0.098	1.990
	3	–0.702	0.738	0.344	0.496	0.115	2.140
BAPTA to Saline	1	0.816	0.768	0.290	2.262	0.494	10.360
	2	0.793	0.774	0.308	2.210	0.477	10.240
	3	1.552	0.771	0.047	4.720	1.024	21.760
BAPTA to L-THA	1	–1.245	0.651	0.059	0.288	0.079	1.050
	2	0.095	0.657	0.885	1.100	0.299	4.040
	3	–0.913	0.653	0.165	0.401	0.110	1.470
YM to DMSO	1	0.064	0.797	0.937	1.066	0.220	5.170
	2	1.348	0.803	0.096	3.848	0.783	18.910
	3	–0.074	0.825	0.929	0.929	0.181	4.760
YM + L-THA to DMSO	1	0.711	0.799	0.376	2.035	0.417	9.930
	2	1.126	0.803	0.164	3.083	0.628	15.140
	3	0.412	0.821	0.617	1.510	0.297	7.670
YM + L-THA-D to L-THA-Saline	1	–1.351	1.057	0.203	0.259	0.032	2.100
	2	0.428	1.059	0.687	1.534	0.188	12.510
	3	–2.053	1.080	0.060	0.128	0.015	1.090
KB to DMSO	1	–0.065	0.804	0.936	0.937	0.190	4.630
	2	0.454	0.828	0.584	1.575	0.305	8.140
	3	–0.243	0.849	0.775	0.784	0.146	4.210
KB + L-THA to DMSO	1	0.086	0.753	0.909	1.090	0.244	4.860
	2	1.426	0.778	0.070	4.162	0.890	19.470
	3	0.831	0.802	0.302	2.295	0.469	11.220
KB + L-THA-D to L-THA-Saline	1	–1.976	1.022	0.056	0.139	0.018	1.050
	2	0.728	1.041	0.486	2.071	0.264	16.270
	3	–1.634	1.066	0.128	0.195	0.024	1.610
NPA to Saline	1	1.741	0.811	0.034	5.704	1.145	28.427
	2	0.754	0.819	0.359	2.125	0.419	10.762
	3	1.606	0.820	0.053	4.981	0.982	25.273
NPA + L-THA to Saline	1	1.904	0.805	0.020	6.714	1.362	33.091
	2	0.201	0.822	0.807	1.223	0.240	6.227
	3	–0.007	0.811	0.993	0.993	0.199	4.949
NPA + L-THA to L-THA	1	–0.158	0.695	0.821	0.854	0.215	3.389
	2	–0.497	0.713	0.487	0.608	0.148	2.497
	3	–2.472	0.699	0.001	0.084	0.021	0.338
Indo to DMSO	1	–0.216	0.733	0.769	0.806	0.188	3.450
	2	2.262	0.757	0.003	9.600	2.141	43.050
	3	1.068	0.779	0.173	2.910	0.623	13.600
Indo + L-THA to DMSO	1	0.054	0.785	0.945	1.056	0.222	5.010
	2	0.559	0.819	0.496	1.749	0.346	8.850
	3	0.652	0.796	0.414	1.919	0.396	9.300
Indo + L-THA-D to L-THA-Saline	1	–2.007	1.046	0.057	0.134	0.017	1.070
	2	–0.046	1.054	0.965	0.955	0.118	7.710
	3	–1.906	1.078	0.080	0.149	0.018	1.260

¹Results based on a mixed effects model using the natural log of AUC as the outcome and including all experimental conditions; ²Difference of means (natural log scale), equivalently ln(Ratio); ³Standard error; ⁴P-value for Wald test; ⁵Exponentiated Difference of Means; ⁶95% confidence interval.