TABLE 4.

Individual pulses – Max change¹.

Contrast	Pulse	Difference (natural log scale)			Ratio
		Mean2	SE3	P-value4	Estimate5	95% CI6
						Lower	Upper
DMSO to Saline	1	0.647	0.392	0.102	1.909	0.878	4.150
	2	0.346	0.402	0.391	1.413	0.637	3.130
	3	0.357	0.412	0.388	1.430	0.632	3.230
L-THA to Saline	1	0.899	0.332	0.008	2.457	1.274	4.740
	2	0.594	0.335	0.079	1.810	0.933	3.514
	3	1.182	0.338	0.001	3.261	1.669	6.372
TFB-TBOA to Saline	1	0.664	0.411	0.109	1.944	0.860	4.391
	2	0.344	0.414	0.408	1.410	0.621	3.204
	3	0.772	0.416	0.066	2.164	0.949	4.935
TFB-TBOA + L-THA to Saline	1	–0.024	0.389	0.950	0.976	0.451	2.113
	2	0.247	0.393	0.530	1.280	0.588	2.790
	3	0.268	0.396	0.499	1.308	0.597	2.867
TFB-TBOA + L-THA to L-THA	1	–0.923	0.339	0.008	0.397	0.203	0.778
	2	–0.346	0.339	0.309	0.707	0.361	1.386
	3	–0.914	0.344	0.009	0.401	0.203	0.793
Receptor Ant. to Saline	1	0.209	0.453	0.645	1.233	0.502	3.030
	2	0.012	0.456	0.980	1.012	0.409	2.500
	3	–0.477	0.479	0.321	0.620	0.240	1.600
Receptor Ant. + L-THA to Saline	1	0.937	0.417	0.027	2.553	1.116	5.840
	2	0.019	0.420	0.964	1.019	0.443	2.340
	3	0.658	0.412	0.114	1.931	0.852	4.380
Receptor Ant. + L-THA to L-THA	1	0.038	0.371	0.918	1.039	0.498	2.170
	2	–0.575	0.370	0.124	0.563	0.270	1.170
	3	–0.524	0.362	0.152	0.592	0.288	1.220
BAPTA to Saline	1	0.187	0.372	0.616	1.206	0.576	2.521
	2	0.601	0.377	0.114	1.825	0.864	3.853
	3	0.708	0.375	0.062	2.030	0.965	4.271
BAPTA to L-THA	1	–0.712	0.318	0.028	0.491	0.261	0.923
	2	0.008	0.321	0.980	1.008	0.534	1.904
	3	–0.474	0.319	0.141	0.623	0.330	1.173
YM to DMSO	1	0.104	0.389	0.790	1.109	0.513	2.400
	2	0.227	0.391	0.563	1.254	0.578	2.720
	3	0.131	0.399	0.744	1.140	0.517	2.510
YM + L-THA to DMSO	1	0.465	0.390	0.235	1.593	0.735	3.450
	2	0.212	0.390	0.589	1.236	0.570	2.680
	3	0.227	0.398	0.570	1.255	0.570	2.760
YM + L-THA-D to L-THA-Saline	1	–0.434	0.512	0.399	0.648	0.235	1.790
	2	–0.382	0.514	0.459	0.682	0.246	1.890
	3	–0.955	0.522	0.070	0.385	0.137	1.080
KB to DMSO	1	–0.233	0.395	0.557	0.792	0.361	1.737
	2	–0.248	0.404	0.541	0.780	0.350	1.739
	3	–0.074	0.412	0.857	0.928	0.410	2.101
KB + L-THA to DMSO	1	–0.088	0.369	0.813	0.916	0.440	1.907
	2	0.182	0.378	0.632	1.199	0.566	2.539
	3	0.297	0.388	0.445	1.346	0.625	2.901
KB + L-THA-D to L-THA-Saline	1	–0.987	0.496	0.049	0.373	0.139	0.998
	2	–0.412	0.505	0.417	0.662	0.243	1.803
	3	–0.885	0.514	0.088	0.413	0.149	1.144
NPA to Saline	1	0.905	0.392	0.023	2.472	1.135	5.381
	2	0.786	0.398	0.051	2.195	0.997	4.832
	3	0.987	0.398	0.015	2.683	1.219	5.903
NPA + L-THA to Saline	1	0.668	0.390	0.090	1.950	0.900	4.228
	2	0.289	0.399	0.471	1.335	0.605	2.945
	3	0.120	0.394	0.761	1.128	0.516	2.465
NPA + L-THA to L-THA	1	–0.231	0.340	0.498	0.794	0.405	1.557
	2	–0.305	0.347	0.381	0.737	0.371	1.466
	3	–1.062	0.341	0.002	0.346	0.176	0.681
Indo to DMSO	1	–0.136	0.359	0.707	0.873	0.428	1.783
	2	0.456	0.368	0.218	1.578	0.761	3.273
	3	0.381	0.377	0.314	1.463	0.694	3.086
Indo + L-THA to DMSO	1	–0.193	0.384	0.617	0.825	0.385	1.769
	2	–0.227	0.388	0.560	0.797	0.370	1.720
	3	0.085	0.397	0.830	1.089	0.496	2.391
Indo + L-THA-D to L-THA-Saline	1	–1.092	0.508	0.034	0.336	0.123	0.918
	2	–0.820	0.512	0.112	0.440	0.160	1.216
	3	–1.097	0.521	0.038	0.334	0.119	0.938

¹Results based on a mixed effects model using the natural log of Max change as the outcome and including all experimental conditions; ²Difference of means (natural log scale), equivalently ln(Ratio); ³Standard error; ⁴P-value for Wald test; ⁵Exponentiated Difference of Means; ⁶95% confidence interval.