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. 2022 Mar 8;23(3):381–403. doi: 10.1007/s11864-021-00932-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Chimeric antigen receptor (CAR) structure. CAR constructs typically consist of an extracellular antigen binding domain (single chain variable fragment (scFv)), a transmembrane domain, and an intracellular signaling domain comprised of a stimulatory domain without (first generation) or with one (second generation) or more (third generation) costimulatory domains. Fourth generation CARs include additional elements such as cytokine secretion or inducible suicide genes. Reproduced with permission from: Barth MJ, Chu Y, Hanley PJ, Cairo MS. Immunotherapeutic approaches for the treatment of childhood, adolescent and young adult non-Hodgkin lymphoma. Br J Haematol. 2016;173(4):597-616. doi: 10.1111/bjh.14078.