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. 2022 Mar 8;23(3):381–403. doi: 10.1007/s11864-021-00932-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Clinical responses to CD19 CAR-NK therapy for CD19 positive lymphoid malignancies. Clinical outcomes of 11 patients treated with cord blood derived, IL-15 expressing, CD19 CAR NK Cell with an inducible caspase 9 suicide gene (iC9/CAR.19/IL-15 CB NK cells). The legend denotes partial response (PR), complete response (CR), minimal residual disease (MRD), and hematopoietic stem cell transplantation (HSCT). Reproduced with permission from: Liu E, Marin D, Banerjee P, Macapinlac HA, Thompson P, Basar R, et al. Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors. N Engl J Med. 2020;382(6):545-53. doi: 10.1056/NEJMoa1910607.