Fig. 4.

Effects of BETi on ovarian tumor growth in vivo ovarian cancer model. A Effect of ABBV-075 and AVA therapy on tumor growth in mice bearing SKOV3ip1 tumors. Control vehicle (n = 10), bevacizumab alone (n = 9), ABBV-075 (n = 8), and combination (n = 7) groups. B Graphs of tumor nodule counts. C Graphs of mouse body weights. D Representative images and quantification graphs of IHC staining for cell proliferation marker (Ki67), vessel density (CD31), and apoptotic marker (cleaved PARP) in the tumor tissue (× 200 magnification). Bar graphs: mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001