Table 2.

Cox proportional hazard ratios (HR) for long-term all-cause mortality.

Different base crowd	Different LVEF	Hazard ratios (95% CI), P-value			P for interaction
		Model 1*	Model 2$	Model 3§
None or Mild MR	LVEF ≥ 50%	Ref	Ref	Ref	0.29
	40% ≤ LVEF <50%	1.65 (1.49–1.82), <0.001	1.65 (1.50–1.83), <0.001	1.45 (1.29–1.63), <0.001
	LVEF <40%	2.38 (2.13–2.66), <0.001	2.27 (2.03–2.54), <0.001	1.79 (1.56–2.05), <0.001
Moderate or Severe MR	LVEF ≥ 50%	Ref	Ref	Ref
	40% ≤ LVEF <50%	1.56 (1.30–1.88), <0.001	1.55 (1.29–1.86), <0.001	1.39 (1.13–1.71), 0.002
	LVEF <40%	2.23 (1.91–2.60), <0.001	2.27 (1.94–2.65), <0.001	1.57 (1.29–1.91), <0.001

^* Unadjusted.

^$ adjusted for age and gender.

^§adjusted for age, gender, hypertension, diabetes mellitus, acute myocardial infarction, congestive heart failure, chronic kidney diseases, atrial fibrillation, stroke, anemia, percutaneous coronary intervention, hyperlipidemia, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, beta-blockers, calcium channel blocker, statins, antiplatelet, mineralocorticoid receptor antagonist, loop diuretics, and oral anticoagulants. MR, mitral regurgitation; LVEF, left ventricular ejection fraction.