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. 2022 Mar 17;12:4609. doi: 10.1038/s41598-022-08618-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of inflammation-related cytokines upregulated by AF16 treatment of RAW264.7 cells (M0-R). AF16 treatment upregulated all shown factors. Values from untreated cells (black columns) are shown next to AF16-treated cells (orange columns), as well as M1 and M2 differentiated macrophages (blue and red columns, respectively). Values marked with ◆ and x indicate where the original values were replaced by the lowest limit of detection or upper limit of quantification, respectively. Values are shown in pg/ml on a logarithmic scale.