TABLE 1.
Pharmacokinetic parameters of moxifloxacin in seven healthy volunteers following a single 400-mg dose
| Administration route and value | Pharmacokinetics in plasma
|
Pharmacokinetics in blister fluid
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h) | t1/2 (h) | AUClast (μg · h/ml) | AUC0–∞ (μg · h/ml) | Urine elimination (% of dose) | Cmax (μg/ml) | Tmax (h) | t1/2 (h) | AUClast (μg · h/ml) | AUC0–∞ (μg · h/ml) | Penetration (%) | |
| Oral | ||||||||||||
| Mean | 4.98 | 1.0 | 8.32 | 39.0 | 45.49 | 15.10 | 2.62 | 3.86 | 10.0 | 32.55 | 40.32 | 83.5 |
| SD | 1.01 | 0.91 | 1.70 | 2.16 | 4.68 | 3.61 | 0.88 | 2.34 | 4.44 | 5.95 | 10.04 | 14.9 |
| Minimum | 3.88 | 0.5 | 7.05 | 36.42 | 39.41 | 10.2 | 1.41 | 2.0 | 5.46 | 24.3 | 28.91 | 60.5 |
| Maximum | 6.76 | 3.0 | 10.9 | 42.84 | 50.58 | 19.9 | 3.84 | 8.0 | 17.47 | 41.15 | 54.80 | 103.4 |
| Intravenous | ||||||||||||
| Mean | 5.09 | 8.17 | 39.13 | 45.34 | 15.2 | 3.23 | 2.43 | 9.54 | 36.33 | 42.74 | 93.7 | |
| SD | 1.11 | 1.58 | 5.80 | 8.0 | 3.40 | 0.43 | 1.13 | 1.33 | 3.9 | 5.31 | 8.3 | |
| Minimum | 3.88 | 6.65 | 28.89 | 32.17 | 8.1 | 2.72 | 1.0 | 7.70 | 30.11 | 36015 | 81.3 | |
| Maximum | 6.80 | 11.26 | 45.23 | 54.26 | 20.0 | 3.82 | 4.0 | 11.54 | 43.28 | 49.94 | 104.2 | |