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. 2022 Mar 17;5:235. doi: 10.1038/s42003-022-03180-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Pericytes derived from neurologically normal post-mortem patients were treated with vehicle or PDGF-BB (10 ng/mL) for 1 or 24 h and gene expression analysed by RNAseq. a Dendrogram of PDGF-BB response in pericytes. Volcano plots comparing b 1 h and c 24 h PDGF-BB treatment to vehicle, with hits highlighted. d Venn diagram of differentially expressed gene lists at 1 and 24 h of PDGF-BB treatment. STRING network analysis of hits from e 1 and f 24 h of PDGF-BB treatment. g Gene ontology analysis and h interaction hub analysis of differentially expressed gene lists. i Expression of pericyte and vascular smooth muscle cell lineage markers identified by Vanlandewijck et al.¹⁵, ranked by fold change. Pericytes derived from the middle temporal gyrus of epilepsy patients were serum starved overnight, then treated with either PDGF-BB (100 ng/mL) or vehicle and lysed. Phosphorylation was detected in lysates using an antibody array. j Representative images, k heatmap of all phosphorylation sites and l levels of selected phosphorylation events in vehicle or PDGF-BB-treated pericytes.