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. 2022 Mar 4;13:831930. doi: 10.3389/fimmu.2022.831930

Figure 1.

Figure 1

Summary of the pathophysiologic conditions occurring during extracorporeal circulation. (A) Artificial biomaterial of the circuit (B) Vascular system of the organs AM, adhesion molecules; Br, bradykinin; C, complement compartment, c, cytokines; Cu, copper; Fe2+, ferrous ion; Fe3+, ferric ion, FI, free iron; H2O2, hydrogen peroxide; He, heme; FIX, factor-9; FX, factor-10; FXI, factor-11; FXII, factor-12; K, kallikrein; Mn, manganese; NO, nitric oxide; O2, oxygen; OH - , hydroxyl; OH., hydroxyl radicalPaO2, partial pressure of arterial oxygen; PK, pre-kallikrein; pTh, prothrombin; RONS, reactive oxygen and nitrogen species; s, selectins; Se, selenium; Th, thrombin; VitC, vitamin C; Zn, zinc; Inline graphic, monocyte; Inline graphic, neutrophil; Inline graphic, red blood cell.