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. 2022 Mar 17;12:4643. doi: 10.1038/s41598-022-08698-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Brain glucose metabolism patterns associated with morphine consumption in F344 and LEW rat strains. PET results in T-maps overlaid on a T2-MRI reference showing increased FDG uptake (hot colors) or decreased FDG uptake (cold colors). PET results in the F344-morphine (left) and LEW-morphine (right) animals compared to the Sal-F344 and Sal-LEW animals respectively, in the acquisition phase (A) and the withdrawal phase (B). (A) F344-morphine animals showed higher FDG uptake in the cortical area and lower FDG uptake in the motor and piriform cortex than the F344-saline animals. LEW-morphine animals showed lower FDG uptake in the somatosensorial and cingulate cortex and thalamus and higher FDG uptake in the cerebellum than the LEW-saline animals. (B) F344-morphine animals showed higher FDG uptake in the left cortex and lower FDG uptake in the restrosplenial and motor cortices than the F344-saline animals. LEW-morphine animals showed higher FDG uptake in the cerebellum and piriform cortex and lower FDG uptake in the cortex, thalamus, hippocampus, and caudate putamen than the LEW-saline animals. LEW-saline (n = 5), LEW-morphine (n = 6), F344-saline (n = 7), and F344-morphine (n = 6). Threshold for statistical significance of p < 0.01. Region of interest (C: cortex, CC: cingulate cortex, Cb: Cerebellum, CP: caudate putamen, Hipp: hippocampus, MC: motor cortex, PirC: piriform cortex, RSC: retrosplenial cortex, Sept: septum, SSC: somatosensorial cortex; Th: thalamus). Side: left (L) and right (R). k: cluster size, T: Student t. FDG uptake: increase (↑) and decrease (↓). p: p value (unc: uncorrected, FWE: family-wise error).