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. 2022 Mar 17;13:1413. doi: 10.1038/s41467-022-28744-4

Fig. 5. SP@AMF prevents the radiation-induced delayed injury in the whole small intestine, weight loss and death.

Fig. 5

a Schematic illustration of the experiment protocol. b Represented IHC images of the small intestine (duodenum, jejunum, and ileum) stained by Masson Trichrome at day 30 after being treated by sham irradiation + PBS (PBS group), 12 Gy abdominal X-ray (IR) + PBS, IR + SP, IR + AMF, and IR + SP@AMF. The blue areas show fibrosis formation. Scale bar =100 µm. Experiment was repeated three times independently with similar results. c Scoring of the degree of delayed intestinal radiation (n = 6 biologically independent animals). The data show means + SD. P was calculated using two-tailed t-test. *P versus IR + PBS group (*<0.05, **<0.01, ***<0.001, n.s., no significance). d Body weight of the mice (n = 6 biologically independent animals). The data show means ± SD. P between group IR + AMF and IR + SP@AMF was calculated using two-tailed t-test. e Survival curves of mice exposed to a fatal dose of abdominal IR (n = 15 biologically independent animals). Median survival: PBS, undefined (>60 days); IR + PBS, 13 days; IR + SP, 16 days; IR + AMF, 32 days; IR + SP@AMF, undefined (>60 days). P was calculated using Log-rank (Mantel-Cox) test.