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. 2022 Mar 17;13:1413. doi: 10.1038/s41467-022-28744-4

Fig. 7. SP@AMF does not influence the regression of orthotopic colorectal tumor while protecting the normal intestine in radiotherapy.

Fig. 7

a Schematic illustration of the experiment protocol. b–d Fluorescence images (b), photographs (c), and weights (d) of the mice’s tumors at day 22 after being treated by sham irradiation + PBS (PBS group), 10 Gy abdominal X-ray (IR) + PBS, IR + Cap@AMF, and IR + SP@AMF (n = 3 biologically independent animals). The data show means + SD. P was calculated using two-tailed t-test. e Represented IHC images of the small intestine stained by Ki67. The black dotted line indicates the Ki67-stained regenerating crypts. Scale bar = 100 µm. Experiment was repeated three times independently with similar results. f Survival curves of mice (n = 15 biologically independent animals). Median survival: PBS, 28 days; SP, 30 days; AMF, 31 days; SP@AMF, 29 days; IR + PBS, 48 days; IR + SP, 47 days; IR + AMF, 53 days; IR + SP@AMF, undefined (>60 days). P was calculated using Log-rank (Mantel-Cox) test.