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. 2022 Mar 17;13:1413. doi: 10.1038/s41467-022-28744-4

Fig. 9. SP@AMF shows higher security in long-term use compared with AMF.

Fig. 9

a Hematological tests and serum biochemicals tests of the mice after the daily administration of PBS, SP, AMF, or SP@AMF for 30 days (n = 5 biologically independent animals). The data show means + SD. P was calculated using two-tailed t-test. WBC white blood cells, RBC red blood cells, HGB hemoglobin, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, MCV mean cell volume, PLT blood platelet, HCT hematocrit, ALT alanine transferase, AST aspartate transferase, BUN blood urea nitrogen, CREA creatinine. b Represented HE images of the major organs of the mice after different treatments for 30 days. Scale bar = 200 μm. Experiment was repeated three times independently with similar results. c Body weight of mice (n = 5 biologically independent animals). The data show means ± SD. P was calculated using two-tailed t-test. d survival curves of mice (n = 10 biologically independent animals). Median survival: PBS, undefined (>30 days); SP, undefined (> 30 days); AMF, undefined (>30 days); SP@AMF, undefined (>30 days). P was calculated using Log-rank (Mantel-Cox) test.