Table 1.
Binding affinities of trans-astaxanthin (TA) and some standard inhibitors for the selected anti-inflammatory protein targets.
| Standard nhibitors | PubChem CID | ∆G energy (Kcal/mol) | |||||
|---|---|---|---|---|---|---|---|
| DmTNF-α | HsTNF-α | DmCasp-1 | HsCasp-1 | DmCox-2 | HsCox-2 | ||
| TA | 5281224 | − 6.8 | − 7.7 | − 7.2 | − 8.3 | − 7.6 | − 7.3 |
| Pralnacasan | 153270 | − 7.8 | − 8.1 | ||||
| Rofecoxib | 5426 | − 6.0 | − 6.5 | ||||
| Thalidomide | 5090 | − 5.8 | − 6.6 | ||||
Dm: Drosophila melanogaster; hm: human, TNF-α: tumour necrosis factor-alpha (Eiger in Drosophila), Caspase-1 (Dcp-1 (Drosophila caspase-1) in Drosophila); and Cox-2 (COII (cytochrome oxidase subunit 2) in D. melanogaster).