Table 3.
Multivariate Cox regression analysis for OS of the SyS patients in the training cohort.
| Characteristics | Full model | AIC-based model | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age at diagnosis | 1.030 (1.019–1.041) | <0.001 | 1.033 (1.022–1.044) | <0.001 |
| Marital status | ||||
| Married | Reference | Reference | ||
| Unmarried | 1.535 (1.092–2.159) | 0.014 | 1.552 (1.114–2.164) | 0.009 |
| Insurance status | ||||
| Any Medicaid | Reference | Reference | ||
| Insured | 0.474 (0.244–0.921) | 0.027 | 0.484 (0.252–0.933) | 0.030 |
| Uninsured | 0.783 (0.509–1.204) | 0.266 | 0.771 (0.505–1.177) | 0.227 |
| Tumor site | ||||
| Head and neck | Reference | Not selected | ||
| Trunk | 1.296 (0.866–1.937) | 0.207 | 1.218 (0.818–1.814) | 0.329 |
| Lung and pleura | 1.991 (1.276–3.104) | 0.002 | 2.078 (1.339–3.224) | 0.001 |
| Extremities | 0.775 (0.550–1.094) | 0.147 | 0.782 (0.555–1.103) | 0.161 |
| Other | 0.348 (0.197–0.614) | <0.001 | 0.327 (0.186–0.577) | <0.001 |
| Tumor size | ||||
| ≤6 cm | Reference | Reference | ||
| 6–10 cm | 1.891 (1.137–3.144) | 0.014 | 1.55 (1.35–1.77) | <0.001 |
| >10 cm | 3.735 (2.289–6.094) | <0.001 | 2.17 (1.89–2.47) | <0.001 |
| Pathology | Not selected | |||
| Biphasic cell | Reference | |||
| Epithelioid cell | 1.205 (0.622–2.334) | 0.581 | — | — |
| Spindle cell | 0.718 (0.444–1.163) | 0.466 | — | — |
| NOS | 1.195 (0.739–1.931) | 0.178 | — | — |
| SEER stage | ||||
| Localized | Reference | Reference | ||
| Regional | 1.088 (0.716–1.653) | 0.694 | 1.148 (0.757–1.739) | 0.514 |
| Distant | 4.734 (3.046–7.356) | <0.001 | 5.063 (3.289–7.792) | <0.001 |
| Radiotherapy | ||||
| Not done | Reference | Reference | ||
| Done | 0.684 (0.484–0.968) | 0.032 | 0.616 (0.439–0.862) | 0.004 |
| Surgery | ||||
| Not done | Reference | Reference | ||
| Done | 0.426 (0.274–0.662) | <0.001 | 0.366 (0.242–0.556) | <0.001 |
Others, American Indian/Alaska Native/Asian/Pacific Islander; NOS, not otherwise specified; AIC, Akaike information criterion; CI, confidence interval; OS, overall survival; SyS, synovial sarcoma; HR, hazard ratio.