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. 2022 Mar 4;12:780078. doi: 10.3389/fonc.2022.780078

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Copyright © 2022 Zhang, Bian, Zhang, Zhang, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of DW-MRI image with treatment response of SD. A case of a 52-year-old man who was diagnosed with MM (IgA kappa light chain, RISS Stage III) is presented here. (A–C) Coronal images of DWI, inverted images, and ADC map at baseline visit. (D–F) Corresponding images of the same patient after four courses of induction chemotherapy (three courses of bortezomib, cyclophosphamide, and dexamethasone + one course of bortezomib, ralidomide, and dexamethasone). The efficacy of induction chemotherapy was evaluated as SD. Diffuse abnormal signal can be seen in the lumbar spine and pelvis. It has been shown that the high signal in the bone marrow of DWI sequence slightly decreased after induction chemotherapy. The mean ADC value of lesions in the scan range also increased from 0.693 × 10⁻³ to 0.775 × 10⁻³ mm²/s.