Table 1.
Baseline characteristic of the cohorts.
| MIMIC-III cohort (n = 8580) | eICU cohort (n = 9749) | |||||
|---|---|---|---|---|---|---|
| Variables | Non-AKI (n = 6,216) |
AKI (n = 2,364) |
P value |
Non-AKI (n = 7,837) |
AKI (n = 1,912) | P value |
| Demographics and vital signs | ||||||
| Age, years | 72.3 ± 13.7 | 75.0 ± 12.7 | <0.001 | 69.9 ± 13.9 | 70.5 ± 13.7 | 0.110 |
| Weight, kg | 80.6 ± 22.3 | 82.6 ± 24.8 | <0.001 | 88.3 ± 29.5 | 91.7 ± 31.0 | <0.001 |
| Temperature, °C | 36.8 ± 0.6 | 36.6 ± 0.7 | <0.001 | 36.8 ± 0.9 | 36.4 ± 0.6 | <0.001 |
| HR, bpm | 102.9 ± 21.2 | 102.1 ± 22.6 | 0.145 | 91.4 ± 18.4 | 92.1 ± 21.0 | 0.183 |
| MAP, mmHg | 75.7 ± 10.5 | 73.8 ± 10.8 | <0.001 | 82.7 ± 20.2 | 75.9 ± 21.4 | <0.001 |
| UO, mL | 1,813 ± 1,171 | 1,639 ± 1,193 | <0.001 | 1,734 ± 1,539 | 1,226 ± 1,033 | <0.001 |
| Laboratory tests | ||||||
| PaO2, mmHg | 169.2 ± 88.7 | 137.7 ± 74.7 | <0.001 | 119.4 ± 64.9 | 122.1 ± 72.2 | 0.112 |
| PaCO2, mmHg | 44.5 ± 12.7 | 44.1 ± 13.4 | 0.247 | 45.3 ± 16.5 | 40.8 ± 16.2 | <0.001 |
| WBC, ×109/L | 12.2 ± 6.1 | 12.2 ± 6.5 | 0.618 | 11.2 ± 5.6 | 12.4 ± 6.5 | <0.001 |
| RBC, ×1012/L | 3.57 ± 0.68 | 3.55 ± 0.70 | 0.138 | 4.00 ± 0.81 | 3.86 ± 0.89 | <0.001 |
| Hematocrit, % | 32.0 ± 6.1 | 31.9 ± 6.1 | 0.228 | 36.2 ± 7.1 | 34.7 ± 7.8 | <0.001 |
| Platelet, ×109/L | 216.2 ± 100.2 | 221.9 ± 105.1 | 0.024 | 228.4 ± 93.9 | 217.7 ± 97.7 | <0.001 |
| SCr, mg/dL | 1.47 ± 1.55 | 2.04 ± 1.33 | <0.001 | 1.90 ± 2.05 | 2.76 ± 2.19 | <0.001 |
| BUN, mg/dL | 28.0 ± 19.9 | 46.1 ± 26.7 | <0.001 | 31.3 ± 20.3 | 50.3 ± 29.0 | <0.001 |
| CK, U/L | 467 ± 900 | 442 ± 926 | 0.246 | 245 ± 266 | 427 ± 474 | <0.001 |
| Lactate, mmol/L | 2.21 ± 1.52 | 2.22 ± 1.62 | 0.832 | 2.31 ± 1.47 | 2.80 ± 2.13 | <0.001 |
| Glucose, mg/dL | 141.8 ± 44.2 | 145.8 ± 48.8 | <0.001 | 165.7 ± 89.6 | 169.3 ± 98.9 | 0.145 |
| Calcium, mmol/L | 2.10 ± 0.21 | 2.09 ± 0.22 | 0.542 | 2.06 ± 0.50 | 2.04 ± 0.48 | 0.091 |
AKI, acute kidney injury; HR, heart rate; MAP, mean aortic pressure; UO, urine output; PaO2, partial arterial oxygen pressure; PaCO2, arterial partial pressure of carbon dioxide; WBC, white blood cell count; RBC, red blood cell count; SCr, Serum creatinine; BUN, blood urine nitrogen; CK, creatine kinase.