Table 1.

Rate constants for ligand exchange from A6 to A0 associated with helicity inversion in methanol at 298 K

Ligand exchange rates (s–1)*		M→P Helicity inversion rates (s–1)		P→M Helicity inversion rates (s–1)		P/M Equilibrium constant†
k ex1	0.10	k A6 +	2.7 × 10−2	k A6 –	3.6 × 10−3	K A6	7.3‡
k ex2	4.5 × 10−3	k A4g +	1.5 × 10−2	k A4g –	1.5 × 10−2	K A4g	0.95
k ex3	6.7 × 10−4	k A2g +	1.0 × 10−4	k A2g –	6.4 × 10−4	K A2g	0.16
		k A0 +	1.2 × 10−5	k A0 –	1.2 × 10−5	K A0	1§

*Pseudo–first-order rate constants. The rate constants k_ex1, k_ex2, and k_ex3 for P and M forms are assumed to be the same for each of the ligand exchange steps.

^†K_S = k_S+/k_S– for S = A6, A4g, A2g, and A0.

^‡K_A6 (=k_A6+/k_A6–) was fixed at 7.3 based on the equilibrium ratio of (P)-A6:(M)-A6 = 88:12.

^§K_A0 (=k_A0+/k_A0–) was fixed at 1 because (P)-A0 and (M)-A0 are enantiomers of each other.