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. 2022 Mar 4;10:786031. doi: 10.3389/fcell.2022.786031

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Copyright © 2022 Hishida, Vazquez-Ferrer, Hishida-Nozaki, Takemoto, Hatanaka, Yoshida, Prieto, Sahu, Takahashi, Reddy, O’Keefe, Rodriguez Esteban, Knoepfler, Nuñez Delicado, Castells, Campistol, Kato, Nakagawa and Izpisua Belmonte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial analysis in Myc cdKO mEPCs. (A) Mitochondrial quantity and activity in Myc cdKO mEPCs treated for 2 days. Data represent the mean with SD (n = 3). *p < 0.0001. (B) Mitochondrial superoxide levels in 4OH-treaed cells. Data represent the mean with SD (n = 3). *p < 0.0001. (C) Rescue effect of Mitotempo. Left, representative image of each condition. Right, quantification of total cell number. Data represent the mean with SE. ns = non-significant, *p < 0.05, **p < 0.0001. (D) Rescue effect of Mitotempo on cell size. *p < 0.0001. (E) Histogram of the cell size distribution. (F) qPCR analysis for Mitotempo-rescued cells. Data represent the mean with SD (n = 3). (G) Proposed model of Myc function supporting self-renewal of the esophageal basal cells.