Fig. 3.

Summary of inhibition measurements for PARPi with PARP1 and PARP2 and comparison to cell-based data. (A) For PARP1, each reported IC₅₀ and K_I value is shown as a point and the line indicates the median value. Our reported measurements for all these inhibitors using a method that avoids the tight-binding limit problem are indicated by black arrows. (B) For PARP2, each reported IC₅₀ and K_I value is shown as a point and the line indicates the median value. (C) The ratio of the median IC₅₀ value for BRCT^+/+ vs. matched BRCT^−/− cells is plotted against the K_I as determined in ref. 65, since these values were determined with proper consideration of the tight-binding limit. All raw values for the points in these plots along with literature references can be found in SI Appendix, Tables S1 and S2.