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Overview of binding pocket for NAD+ in the catalytic domain of PARP1. (Left) The ribbon structure of the catalytic domain of PARP1 is shown in cyan with the nonhydrolyzable NAD+ analog (BAD) shown in green (Protein Data Bank [PDB] ID 6BHV). (Right) The pocket for binding BAD is visualized with the protein surface shown in cyan. Note that the nicotinamide ring sits in the deepest pocket of the active site.
