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. 2022 Mar 10;119(11):e2117113119. doi: 10.1073/pnas.2117113119

Fig. 4.

Fig. 4.

Differential effects of cocaine on the liver metabolome. (A) Pie charts representing the percentage of liver metabolites of each class displaying different levels at ZT11 versus ZT23 in saline- or cocaine-treated WT or iMSN-D2RKO mice as indicated. (B) Number of metabolites up-regulated at either ZT11 or ZT23 in saline- or cocaine-treated mice as indicated. (C) Volcano plots of metabolites at ZT11 and ZT23 in livers from WT or iMSN-D2RKO mice treated with saline or cocaine. Metabolites with significant changes between time points were identified when the P value was <0.05 (red dots); n = 5, ANOVA Benjamini–Hochberg corrected, cutoff, P < 0.05; pVal, P value.