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. 2022 Mar 10;119(11):e2117113119. doi: 10.1073/pnas.2117113119

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Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Differential effects of cocaine on the liver metabolome. (A) Pie charts representing the percentage of liver metabolites of each class displaying different levels at ZT11 versus ZT23 in saline- or cocaine-treated WT or iMSN-D2RKO mice as indicated. (B) Number of metabolites up-regulated at either ZT11 or ZT23 in saline- or cocaine-treated mice as indicated. (C) Volcano plots of metabolites at ZT11 and ZT23 in livers from WT or iMSN-D2RKO mice treated with saline or cocaine. Metabolites with significant changes between time points were identified when the P value was <0.05 (red dots); n = 5, ANOVA Benjamini–Hochberg corrected, cutoff, P < 0.05; pVal, P value.